Properties and Dissolution Methods of Hydroxypropyl Methyl Cellulose

Hydroxypropylmethylcellulose (HPMC) is a non-toxic, tasteless, odorless white to off-white powder, commonly used in pharmaceutical, construction, cosmetics and other industries. It has the following properties:
  1. Thermal stability: HPMC does not decompose or degrade under high temperature conditions.
  2. Solubility: HPMC is soluble in water, ethylene glycol, and other water-soluble solvents, but is difficult to dissolve in organic solvents.
  3. Swelling ability: HPMC has good swelling ability and can increase the viscosity of the solution.
  4. Stability: HPMC solution has good stability and is not easily spoiled or decomposed.
  5. Biodegradability: HPMC can be hydrolyzed by enzymes in the body into non-toxic metabolites, which does not pollute the environment.

Regarding the dissolution method of HPMC, the following steps can be taken:

  1. Add the required amount of HPMC to pure water or ethylene glycol at room temperature, and stir well to avoid the formation of lumps.
  2. Heat to 80-90℃, stirring until completely dissolved.
  3. Cool to room temperature, and continue stirring to make the solution uniform.

It should be noted that when dissolving HPMC, you can directly add hot water and stir, the HPMC is fully dissolved and dispersed, and then add the remaining cold water or cool down. Stirring is also required when cooling down to prevent HPMC from precipitation and stratification. Stirring is not required until the viscosity starts.

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